AB21™ probiotic strains show specific properties on immunity enhancement through a triple mechanism of action :

AB21
AB21 Mechanisms of Action
 

AB21™ probiotic strains, specially L. plantarum KABP™ 033 naturally overexpress a gene (plnG) that activates the immune system

1) Immune Cell Stimulation

 
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High expression of plnG allows a cross-talk between AB21™ probiotic strains and several immunity cells, including dendritic cells (DCs), macrophages, monocytes and lymphocytes.
These cells are key players in the adaptive immune response, activating the production of specific immunoglobulins (antibodies).

2) Enhancement of gut barrier function

AB21™ strengthens the gut barrier and decreases local inflammation due to the production of polyphosphates.

 
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When the intestinal barrier is damaged and tight junctions are faulty the gut epithelial allows pro-inflammatory substances to enter.

That is known as increased intestinal permeability

General inflammation condition

increased 

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Polyphosphates reinforce gut epithelial tight junctions and also alleviate local inflammation

Intestinal permeability is improved, enhancing gut barrier function

 

AB21™ promotes the production of two molecules that balance the inflammatory response.

3) Anti-Inflammatory Activity

Acetylcholine

Acetate

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Through the cholinergic anti-inflammatory pathway, acetylcholine binds to the nicotinic  acetylcholine receptor α7 subunit, inhibits the release of TNF-alfa  and, as result, reduces inflammatory response

Acetate is the major short-chain fatty acid produced by commensal bacteria in the gut and is known because shows: Anti-inflammatory activity and serves as a nutrient source for epithelial cells of the mucosa